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| Main Authors: | , , , |
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| Format: | Preprint |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2401.08607 |
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| _version_ | 1866914642997018624 |
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| author | Wu, Kaichao Jelfs, Beth Neville, Katrina Fang, Qiang |
| author_facet | Wu, Kaichao Jelfs, Beth Neville, Katrina Fang, Qiang |
| contents | Background: The brain's functional network constantly adapts to external changes. However, the mechanisms underlying this dynamic adaptive behavior in stroke patients with motor injuries and its role in post-stroke motor recovery remain poorly understood.
Method: This study conducted a long-term investigation involving 15 first-stroke patients. Each participant underwent five fMRI scans distributed equally over a six-month period. Using functional neuroimaging data, time-varying functional modularity in post-stroke patients was detected, and subsequently, the dynamic brain behaviors, including recruitment, integration, and flexibility, along with their longitudinal changes, were assessed.
Results: Our findings reveal that stroke lesions lead to significant and enduring alterations in all three dynamic behaviors within functional brain networks. Furthermore, during the six-month recovery period, patients who exhibited good and poor recovery showed notable differences in recruitment and flexibility, indicating distinct recovery trajectories for these groups. Notably, when predicting post-stroke recovery status, whole-brain recruitment emerged as a robust and reliable feature, achieving an AUC of 85.93
Significance: Our study offers a comprehensive depiction of dynamic brain behavior in the post-ischemic-stroke brain, with a focus on longitudinal changes concurrent with functional recovery. These dynamic patterns hold promise as valuable tools for evaluating and predicting motor recovery following stroke. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2401_08607 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Dynamic Brain Behaviours in Stroke: A Longitudinal Investigation Based on fMRI Analysis Wu, Kaichao Jelfs, Beth Neville, Katrina Fang, Qiang Neurons and Cognition Background: The brain's functional network constantly adapts to external changes. However, the mechanisms underlying this dynamic adaptive behavior in stroke patients with motor injuries and its role in post-stroke motor recovery remain poorly understood. Method: This study conducted a long-term investigation involving 15 first-stroke patients. Each participant underwent five fMRI scans distributed equally over a six-month period. Using functional neuroimaging data, time-varying functional modularity in post-stroke patients was detected, and subsequently, the dynamic brain behaviors, including recruitment, integration, and flexibility, along with their longitudinal changes, were assessed. Results: Our findings reveal that stroke lesions lead to significant and enduring alterations in all three dynamic behaviors within functional brain networks. Furthermore, during the six-month recovery period, patients who exhibited good and poor recovery showed notable differences in recruitment and flexibility, indicating distinct recovery trajectories for these groups. Notably, when predicting post-stroke recovery status, whole-brain recruitment emerged as a robust and reliable feature, achieving an AUC of 85.93 Significance: Our study offers a comprehensive depiction of dynamic brain behavior in the post-ischemic-stroke brain, with a focus on longitudinal changes concurrent with functional recovery. These dynamic patterns hold promise as valuable tools for evaluating and predicting motor recovery following stroke. |
| title | Dynamic Brain Behaviours in Stroke: A Longitudinal Investigation Based on fMRI Analysis |
| topic | Neurons and Cognition |
| url | https://arxiv.org/abs/2401.08607 |