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Bibliographic Details
Main Authors: Hai, Fahmida, Nirzhor, Saif, Khan, Rubayat, Roosan, Don
Format: Preprint
Published: 2025
Subjects:
Online Access:https://arxiv.org/abs/2506.19086
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Table of Contents:
  • This paper introduces a tamper-resistant framework for large language models (LLMs) in medical applications, utilizing quantum gradient descent (QGD) to detect malicious parameter modifications in real time. Integrated into a LLaMA-based model, QGD monitors weight amplitude distributions, identifying adversarial fine-tuning anomalies. Tests on the MIMIC and eICU datasets show minimal performance impact (accuracy: 89.1 to 88.3 on MIMIC) while robustly detecting tampering. PubMedQA evaluations confirm preserved biomedical question-answering capabilities. Compared to baselines like selective unlearning and cryptographic fingerprinting, QGD offers superior sensitivity to subtle weight changes. This quantum-inspired approach ensures secure, reliable medical AI, extensible to other high-stakes domains.