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| Format: | Recurso digital |
| Idioma: | anglès |
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Zenodo
2026
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| Accés en línia: | https://doi.org/10.1002/ueg2.70150 |
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| author | Mañosa M Calafat M Ricart E Nos P Iglesias E Riestra S Mesonero F Calvo M Guardiola J Hernández V Rivero M Carpio D Mínguez M Alba C Martín-Arranz MD Vela M Gomollón F García-López S Casbas AG Calvet X González-Muñoza C Barrio J Gisbert JP Sicilia B Pérez-Calle JL Bujanda L Esteve M Ramos L Varela P Sierra M Merino O Bermejo F Barreiro-de Acosta M Perez AR Márquez-Mosquera L García-Bosch O Rodríguez-Lago I Lorente Poyatos RH García Sepulcre MF Maroto N Vega P Monfort D San Martín LZ Busquets D Martinez-Montiel P Riera J Alcain G Llaó J Marin N Marin-Jimenez I Sesé E Van Domselaar M Huguet JM Ginard D Bas-Cutrina F Ber Y Roncero O Lucendo AJ López-García A Menacho M Almela P Ponferrada Á Coronel AF Maestro S de Jesús Martínez-Pérez T Vilafranca CM Argüelles F Legido J Gilabert P Charro M Trapero AM Fernández H Frago S Villalba LH Muñoz E Domènech E |
| author_facet | Mañosa M Calafat M Ricart E Nos P Iglesias E Riestra S Mesonero F Calvo M Guardiola J Hernández V Rivero M Carpio D Mínguez M Alba C Martín-Arranz MD Vela M Gomollón F García-López S Casbas AG Calvet X González-Muñoza C Barrio J Gisbert JP Sicilia B Pérez-Calle JL Bujanda L Esteve M Ramos L Varela P Sierra M Merino O Bermejo F Barreiro-de Acosta M Perez AR Márquez-Mosquera L García-Bosch O Rodríguez-Lago I Lorente Poyatos RH García Sepulcre MF Maroto N Vega P Monfort D San Martín LZ Busquets D Martinez-Montiel P Riera J Alcain G Llaó J Marin N Marin-Jimenez I Sesé E Van Domselaar M Huguet JM Ginard D Bas-Cutrina F Ber Y Roncero O Lucendo AJ López-García A Menacho M Almela P Ponferrada Á Coronel AF Maestro S de Jesús Martínez-Pérez T Vilafranca CM Argüelles F Legido J Gilabert P Charro M Trapero AM Fernández H Frago S Villalba LH Muñoz E Domènech E |
| contents | BACKGROUND: Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population. METHODS: This was a case-control study including all adult patients with CD from the ENEIDA registry who had undergone a first intestinal resection with ileo-colonic anastomosis. Patients were grouped according to their age at the time of the first surgery in older (over 60 years) subjects and controls (between 18 and 60 years of age). RESULTS: A total of 3982 (535 older subjects and 3454 controls) underwent a first intestinal resection for CD with an ileo-colonic anastomosis. Time from CD diagnosis to surgery was significantly longer in older patients (114 ± 128 vs. 93 ± 97 months; p < 0.001). Older patients also had a lower proportion of penetrating CD (25% vs. 39%; p < 0.0001) and perianal disease (14% vs. 25%; p < 0.0001). A significantly lower proportion of older patients started preventive therapies for POR (32% vs. 51%; p < 0.0001). The cumulative risk of surgical POR was 3.2%, 5.3% and 10.1% in the older group and 3.6%, 6.6% and 14.2% in the control group at three, five and 10 years, respectively (p = 0.093). In the multivariate logistic regression analysis, only prevention with thiopurines was associated with a lower risk of surgical POR. CONCLUSIONS: Although postoperative preventive therapy with immunomodulators or biologicals is prescribed less often in older patients after a first intestinal resection, they develop surgical POR as often as younger adult patients. © 2025 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_1002_ueg2_70150 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. Mañosa M Calafat M Ricart E Nos P Iglesias E Riestra S Mesonero F Calvo M Guardiola J Hernández V Rivero M Carpio D Mínguez M Alba C Martín-Arranz MD Vela M Gomollón F García-López S Casbas AG Calvet X González-Muñoza C Barrio J Gisbert JP Sicilia B Pérez-Calle JL Bujanda L Esteve M Ramos L Varela P Sierra M Merino O Bermejo F Barreiro-de Acosta M Perez AR Márquez-Mosquera L García-Bosch O Rodríguez-Lago I Lorente Poyatos RH García Sepulcre MF Maroto N Vega P Monfort D San Martín LZ Busquets D Martinez-Montiel P Riera J Alcain G Llaó J Marin N Marin-Jimenez I Sesé E Van Domselaar M Huguet JM Ginard D Bas-Cutrina F Ber Y Roncero O Lucendo AJ López-García A Menacho M Almela P Ponferrada Á Coronel AF Maestro S de Jesús Martínez-Pérez T Vilafranca CM Argüelles F Legido J Gilabert P Charro M Trapero AM Fernández H Frago S Villalba LH Muñoz E Domènech E Crohn's disease older postoperative recurrence surgery BACKGROUND: Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population. METHODS: This was a case-control study including all adult patients with CD from the ENEIDA registry who had undergone a first intestinal resection with ileo-colonic anastomosis. Patients were grouped according to their age at the time of the first surgery in older (over 60 years) subjects and controls (between 18 and 60 years of age). RESULTS: A total of 3982 (535 older subjects and 3454 controls) underwent a first intestinal resection for CD with an ileo-colonic anastomosis. Time from CD diagnosis to surgery was significantly longer in older patients (114 ± 128 vs. 93 ± 97 months; p < 0.001). Older patients also had a lower proportion of penetrating CD (25% vs. 39%; p < 0.0001) and perianal disease (14% vs. 25%; p < 0.0001). A significantly lower proportion of older patients started preventive therapies for POR (32% vs. 51%; p < 0.0001). The cumulative risk of surgical POR was 3.2%, 5.3% and 10.1% in the older group and 3.6%, 6.6% and 14.2% in the control group at three, five and 10 years, respectively (p = 0.093). In the multivariate logistic regression analysis, only prevention with thiopurines was associated with a lower risk of surgical POR. CONCLUSIONS: Although postoperative preventive therapy with immunomodulators or biologicals is prescribed less often in older patients after a first intestinal resection, they develop surgical POR as often as younger adult patients. © 2025 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. |
| title | Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry. |
| topic | Crohn's disease older postoperative recurrence surgery |
| url | https://doi.org/10.1002/ueg2.70150 |