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Պահպանված է:
Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: Peña, M., Lazzari, L., Martinez, D.F., Ciceri, F., Balaguer-Roselló, A., Sanz, J., Pascual, M.J., Benzaquén, A., Piñana, J.L., Salas, M.Q., Nieto Vázquez, A., Español, I., Huguet, M., Bento, L., Sáez, A.J., Barba-Suñol, P., Filaferro, S., Carbonell-Asins, J.A., Peña, C., Mussetti, A., Greco, R.
Ձևաչափ: Recurso digital
Լեզու:անգլերեն
Հրապարակվել է: Zenodo 2026
Խորագրեր:
allogeneic haematopoietic cell transplantation
lymphoid malignancies
post-transplant cyclophosphamide
reduced-intensity conditioning
treosulfan/fludarabine
Առցանց հասանելիություն:https://doi.org/10.1111/bjh.70367
Ցուցիչներ: Ավելացրեք ցուցիչ
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
Բովանդակություն:
  • Allogeneic haematopoietic cell transplantation (alloHCT) remains a potentially curative strategy for relapsed or refractory lymphoid malignancies, even in the post-chimeric antigen receptor T-cell and bispecific antibody era. While reduced-intensity conditioning regimens offer lower non-relapse mortality (NRM), relapse rates remain high, and optimal conditioning strategies in the setting of post-transplant cyclophosphamide (PTCy) prophylaxis remain undefined. In this retrospective, international multicentre study, the primary end-point was NRM. We compared treosulfan/fludarabine (Treo/Flu) versus thiotepa/busulfan/fludarabine (TBF) in 178 adults with lymphoid malignancies undergoing first alloHCT with PTCy and peripheral blood grafts. Three-year NRM was 14.0% with Treo/Flu versus 33.0% with TBF. On multivariate analysis, Treo/Flu was associated with significantly lower 3-year NRM (hazard ratio [HR] 0.44; 95% confidence interval [CI], 0.22–0.87; p = 0.018). Conditioning regimen was not independently associated with overall survival (OS) or progression-free survival (PFS), and relapse incidence was similar between regimens. Moderate to severe chronic graft-versus-host disease (GVHD) was higher with Treo/Flu (26.0% vs. 9.9%; HR 2.43; 95% CI, 1.09–5.43; p = 0.03), while GVHD-free/relapse-free survival (GFRS) was comparable. Findings were consistent in a prespecified propensity score-matched sensitivity analysis. These findings support Treo/Flu as a potentially safer reduced-toxicity conditioning option than TBF in the context of PTCy-based GVHD prophylaxis for lymphoid malignancies and warrant prospective validation. © 2026 British Society for Haematology and John Wiley & Sons Ltd.

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