Αποθηκεύτηκε σε:
| Κύριος συγγραφέας: | |
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| Μορφή: | Recurso digital |
| Γλώσσα: | Αγγλικά |
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Zenodo
2025
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| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.31466/kfbd.1607109 |
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| _version_ | 1866901493437693952 |
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| author | SILME, RAGIP SONER |
| author_facet | SILME, RAGIP SONER |
| contents | <p>The emergence of human papillomavirus (HPV) among the human population in different regions of the world has heightened the interest for new treatment methods. Molecular docking is a reliable and predictive method for screening of new potential antiviral molecules against pathogens. The retrieved 42 high-quality whole-genome sequences of HPV were analyzed in search of a stable region which is exist in the genome. The protein encoded by this stable region was targeted for protein-ligand interaction. Consequently, a target constant region which is responsible for encoding the Cterminal domain (monomer) of the HPV45 oncoprotein E7 (PDB: 2ewl) with various regulatory functions for the virus was detected. A ligand “Pheophorbide a (C35H36N4O5)” interacts with this protein, which could be used against HPV. Pheophorbide a has also been commercially used for cancer treatments due to its anti-proliferative effects and photosensitizer property in photodynamic therapy. This possible antiviral property of Pheophorbide a should be tested on other high-risk and low-risk Papillomaviruses since the E7 oncoprotein also plays a central role in many other HPV types. The predictive results need confirmation with further clinical and <em>in vitro</em> studies. The findings will provide new insights into HPV-human cell interactions, induced immunity, and new methods for HPV treatment.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_31466_kfbd_1607109 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Repurposing Pheophorbide a as an Antiviral Molecule for Human Papillomavirus type 16 SILME, RAGIP SONER Antiviral Anticancer HPV Human papillomavirus Pheophorbide a <p>The emergence of human papillomavirus (HPV) among the human population in different regions of the world has heightened the interest for new treatment methods. Molecular docking is a reliable and predictive method for screening of new potential antiviral molecules against pathogens. The retrieved 42 high-quality whole-genome sequences of HPV were analyzed in search of a stable region which is exist in the genome. The protein encoded by this stable region was targeted for protein-ligand interaction. Consequently, a target constant region which is responsible for encoding the Cterminal domain (monomer) of the HPV45 oncoprotein E7 (PDB: 2ewl) with various regulatory functions for the virus was detected. A ligand “Pheophorbide a (C35H36N4O5)” interacts with this protein, which could be used against HPV. Pheophorbide a has also been commercially used for cancer treatments due to its anti-proliferative effects and photosensitizer property in photodynamic therapy. This possible antiviral property of Pheophorbide a should be tested on other high-risk and low-risk Papillomaviruses since the E7 oncoprotein also plays a central role in many other HPV types. The predictive results need confirmation with further clinical and <em>in vitro</em> studies. The findings will provide new insights into HPV-human cell interactions, induced immunity, and new methods for HPV treatment.</p> |
| title | Repurposing Pheophorbide a as an Antiviral Molecule for Human Papillomavirus type 16 |
| topic | Antiviral Anticancer HPV Human papillomavirus Pheophorbide a |
| url | https://doi.org/10.31466/kfbd.1607109 |