Salvato in:
| Autori principali: | , , |
|---|---|
| Natura: | Recurso digital |
| Lingua: | inglese |
| Pubblicazione: |
Zenodo
2025
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| Accesso online: | https://doi.org/10.5281/zenodo.14787239 |
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Sommario:
- <p><em><span>Decreased gastric acid secretion increases the bioavailability of acid-sensitive drugs (e.g., penicillins) and decreases the bioavailability of weakly acidic drugs (e.g., phenobarbital).</span></em></p> <p><em><span>Decreased bile acids reduce the bioavailability of lipophilic drugs (e.g. diazepam).</span></em></p> <p><em><span>When enteral medications are administered to infants younger than 3 months of age, delayed gastric emptying and intestinal motility increase the time required to reach therapeutic concentrations. Drug-metabolizing enzymes present in the infant's intestines are another reason for reduced drug absorption. Infants with congenital intestinal atresia, those who have had their intestines surgically removed, and those who require the use of a jejunal feeding tube may have specific malabsorption depending on the size and location of the missing or bypassed intestine. You should also consider how the type of food you are eating may affect gastric emptying (e.g., solid or liquid).</span></em></p>