שמור ב:
| מחבר ראשי: | |
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| פורמט: | Recurso digital |
| שפה: | |
| יצא לאור: |
Zenodo
2025
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| גישה מקוונת: | https://doi.org/10.5281/zenodo.15182129 |
| תגים: |
הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
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תוכן הענינים:
- <p>Tolerized responses to innate immune ligands like LPS are best understood as primed responses informed by an innate immune epigenetic memory. Subsequent transcriptional responses following exposure to LPS in the short or long run are thus tailored to meet cellular needs, executed through titrating availability of nuclear factors that transduce PAMP signals. We measured total transcription in LPS-tolerized or LPS “trained” cells to define and quantitatively characterize changes in expression of nuclear factors associated with LPS tolerance. We describe here a set of nuclear factors, including epigenetic molecules (I e. TDRD7), general transcription factors subunits (i.e. GTF2B), and nuclear receptor Sp110 whose expression was activated or repressed in the LPS-tolerized state. Induction of EZH2, a component of the polycomb repressive complex 2 (PRC2) was a transcriptional feature of LPS tolerance, along with GADD45A/B, suggesting that histone lysine methylation and methylation of the DNA were also important for tolerized responses to gram-negative bacteria. </p> <p> </p>