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| Formato: | Recurso digital |
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Zenodo
2025
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| Acceso en liña: | https://doi.org/10.5281/zenodo.15201463 |
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Table of Contents:
- <div> <p><em><span>The<span> </span>bioavailability<span> </span>of<span> </span>poorly<span> </span>soluble<span> </span>drugs<span> </span>is<span> </span>a<span> </span>critical<span> </span>concern<span> </span>in<span> </span>pharmaceutical<span> </span>development. One of the primary strategies to enhance drug solubility and, subsequently, bioavailability is through<span> </span>the<span> </span>use<span> </span>of<span> </span>excipients.<span> </span>Excipients,<span> </span>which<span> </span>are<span> </span>inert<span> </span>substances<span> </span>used<span> </span>in<span> </span>drug<span> </span>formulations, can<span> </span>play various<span> </span>roles in improving the<span> </span>dissolution rate<span> </span>and solubility<span> </span>of<span> </span>poorly<span> </span>soluble<span> </span>drugs, thereby<span> </span>enhancing<span> </span>their<span> </span>bioavailability.<span> </span>This<span> </span>abstract<span> </span>evaluates<span> </span>the<span> </span>impact of<span> </span>different<span> </span>types<span> </span>of excipients—such as surfactants, co-solvents, polymers, and lipid-based excipients—on the bioavailability of drugs with low aqueous solubility.</span></em></p> <p><em><span>Recent studies have demonstrated that excipients can improve bioavailability by several mechanisms: enhancing drug dissolution, improving drug absorption through modulation of the<span> </span>gastrointestinal<span> </span>environment,<span> </span>and<span> </span>altering<span> </span>the<span> </span>pharmacokinetic<span> </span>profile<span> </span>of<span> </span>drugs.<span> </span></span></em></p> <p><em><span>The oral bioavailability of poorly soluble drugs, often classified as Biopharmaceutical Classification System (BCS) Class II and IV compounds, remains a key obstacle in pharmaceutical development. Inadequate solubility limits dissolution, leading to poor absorption and suboptimal drug efficacy. Excipients, non-active components in drug formulations, play a pivotal role in overcoming these limitations by modifying the drug’s physicochemical properties and promoting more efficient absorption.</span></em></p> <p><strong><em><span>Keywords: </span></em></strong><em><span>Excipients, Bioavailability enhancement, Poorly soluble drugs, Solubility enhancement, Pharmaceutical formulation, Drug absorption. Solid dispersion, Permeability enhancement, Pharmacokinetic Drug, solubilisation, Self-emulsifying, drug delivery systems (SEDDS), Bio enhancers.</span></em></p> </div>