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| Format: | Recurso digital |
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Zenodo
2025
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| Accés en línia: | https://doi.org/10.5281/zenodo.15337652 |
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- <p>This is an archive of the gitlab repository https://gitlab.com/dnjst/fmi2024/ at the time of publication.</p> <p> </p> <p>This contains the computational notebooks and databases for the analysis for the paper:</p> <p>Stadtmauer, D.J.†, Basanta Martínez, S.†, Maziarz, J,D., Cole, A.G., Dadgas, G., Rae Smith, G., van Breukelen, F., Pavličev, M., Wagner, G.P., 2025. “Cell type and cell signaling innovations at the fetal-maternal interface.” Nature Ecology & Evolution.</p> <p> </p> <p>BioRxiv version DOI: https://doi.org/10.1101/2024.05.01.591945 </p> <p> </p> <p>This also contains an archive of cell-cell communication plotting scripts from the gitlab repository https://gitlab.com/dnjst/chinpy, version 0.0.55 at the time of publication.</p> <p> </p> <p><strong>Manuscript Abstract</strong>:</p> <p>How fetal and maternal cell types have co-evolved to enable mammalian placentation poses a unique evolutionary puzzle. Here, we integrate and compare single-cell transcriptomes from six species bracketing therian mammal diversity: opossum (a marsupial), Malagasy common tenrec (an afrotherian), mouse and guinea pig (rodents), and macaque and human (primates). We identify a conserved transcriptomic signature of invasive trophoblast across eutherians, likely representing a cell type family that radiated with the evolution of hemochorial placentation. In the maternal stroma, comparative analysis reveals that the endocrine decidual cell evolved from an immunomodulatory predecidual cell type retained in Tenrec and resembling early human decidua. Fetal and maternal cell signaling shows a pronounced tendency towards disambiguation – the exclusive expression of ligands by only one partner – although few ligand-receptor pairs follow an escalatory arms race dynamic. Finally, we reconstruct the uteroplacental cell-cell communication networks of extinct mammalian ancestors, identifying signaling innovations and widespread integration of fetal trophoblast and maternal decidual cells into signaling networks. Together, these results reveal a dynamic history of cell type innovation and co-evolution at the fetal-maternal interface.</p>