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| 第一著者: | |
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| フォーマット: | Recurso digital |
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| 出版事項: |
Zenodo
2025
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| 主題: | |
| オンライン･アクセス: | https://doi.org/10.5281/zenodo.15538501 |
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目次:
- <p><span lang="EN-US">Nanoparticle-based sustained release tablets represent a transformative advancement in the field of pharmaceutical technology, offering numerous benefits over conventional drug delivery systems. These formulations are designed to release therapeutic agents at a controlled rate over an extended period, thereby improving drug bioavailability, reducing dosing frequency, and enhancing patient adherence. By incorporating drugs into nanoparticles, it is possible to modify pharmacokinetic profiles, ensure consistent plasma drug levels, and minimize peak-trough fluctuations, which can lead to adverse effects or reduced efficacy. Nanoparticles also provide significant advantages such as improved solubility of poorly water-soluble drugs, protection of labile compounds from degradation in the gastrointestinal environment, and targeted delivery to specific sites of action. Among the various strategies employed, ionic gelation and dual ionic gelation have emerged as efficient, mild, and scalable methods for nanoparticle preparation, particularly for hydrophilic and macromolecular drugs. This review comprehensively examines different types of nanoparticles, preparation methodologies, and their integration into sustained release tablets. It further explores the physicochemical and formulation factors affecting drug release profiles. Recent advancements, case studies, and ongoing challenges are also addressed, highlighting the potential and future prospects of nanoparticle-enabled sustained release systems in improving therapeutic outcomes and drug delivery efficiency</span><span lang="EN-US">.</span></p>