Kaydedildi:
| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Recurso digital |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
Zenodo
2025
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| Konular: | |
| Online Erişim: | https://doi.org/10.5281/zenodo.15623249 |
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İçindekiler:
- <p><strong><span lang="pl">Abstract</span></strong></p> <p><span lang="pl"> </span></p> <p><span lang="pl">Edible vaccines represent an innovative approach to immunization, offering a promising alternative to traditional injectable vaccines. Produced in genetically modified plants or microorganisms, these vaccines are administered orally, eliminating the need for needles, cold chain storage, and trained medical personnel. They stimulate both mucosal and systemic immunity, providing early protection against pathogens at entry points such as the gastrointestinal tract. Key advantages include lower production costs, ease of distribution, and higher public acceptance, particularly in children and resource-limited settings. A notable success is the plant-based COVID-19 vaccine COVIFENZ®, developed using virus-like particles (VLPs) from <em>Nicotiana benthamiana</em>, which has been approved in Canada.</span></p> <p><span lang="pl">Despite their potential, edible vaccines face challenges, including dosage standardization, risk of immune tolerance, antigen degradation in the digestive system, and public skepticism toward genetically modified organisms. Additionally, heat-sensitive plant-based vaccines may lose efficacy if cooked. Ongoing research aims to optimize adjuvants, enhance antigen stability, and expand applications beyond infectious diseases, including autoimmune therapies.</span></p> <p><span lang="pl">Edible vaccines hold significant promise for global health, particularly in developing countries with limited healthcare infrastructure. Their scalability, cost-effectiveness, and needle-free administration could revolutionize vaccination strategies, especially during pandemics. While further clinical and regulatory advancements are needed, edible vaccines may soon transform preventive medicine, making immunization more accessible and acceptable worldwide.</span></p>