Պահպանված է:
| Հիմնական հեղինակներ: | , , , , , , , |
|---|---|
| Ձևաչափ: | Recurso digital |
| Լեզու: | անգլերեն |
| Հրապարակվել է: |
Zenodo
2022
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| Խորագրեր: | |
| Առցանց հասանելիություն: | https://doi.org/10.5281/zenodo.15717331 |
| Ցուցիչներ: |
Ավելացրեք ցուցիչ
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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Բովանդակություն:
- <p>Release kinetics of a drug from the ceramic drug delivery carrier depends on various parameters such as nature of<br>the ceramic, binder, porosity of the ceramics, particle size of the ceramic and, solubility as well as nature of the<br>drug. In the present study effect of formulation on the release kinetics of the drug from hydroxyapatite, the carrier<br>was studied. Hydroxyapatite and Zirconia were taken as ceramic carriers and the model drugs taken for comparison<br>are ciprofloxacin hydrochloride and levofloxacin whereas polyvinyl alcohol was added as a binder. Ciprofloxacin<br>hydrochloride shows a sustained release whereas levofloxacin shows burst release from the ceramic drug carrier.<br>The percentage of polyvinyl alcohol added to the drug played a vital role as a higher concentration of the polymer<br>affects the stability of the drug carrier. Hydroxyapatite/zirconia composite shows sustained release (29%) when<br>compared to pure hydroxyapatite (43%) and zirconia (37%) after 6 hours of immersion in simulated body fluid.<br>Release kinetics shows that the solubility of the drug, concentration of the binder, and the ratio of ceramics in the<br>composites decides the release kinetics of the drug from the drug delivery carrier.</p>