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Detalhes bibliográficos
Autor principal: Mule Munjaji*, Panchbhai Vivek, Thaware Pratibha
Formato: Recurso digital
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Publicado em: Zenodo 2025
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Acesso em linha:https://doi.org/10.5281/zenodo.16448068
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Sumário:
  • <p><span lang="EN">A simple, Accurate, precise method was developed for the simultaneous estimation of the Norfloxacin and Tinidazole in Tablet dosage form. Chromatogram was run through SunFire C18 Column3.5 µm, 4.6 mm X 150 mm. Mobile phase containing Phosphate Buffer and Acetonitrile and Methanol in the ratio of 60:30:10 was pumped through column at a flow rate of 0.8 ml/min. Temperature was maintained at 26°C. Optimized wavelength for Norfloxacin and Tinidazole was 290 nm. Retention time of Norfloxacin and Tinidazole were found to be 2.290 min and 2.848min. %RSD of the Norfloxacin and Tinidazole were and found to be 0.2 and 0.3 respectively. %Recovery was Obtained as 100.30% and 99.97% for Norfloxacin and Tinidazole. LOD, LOQ values were obtained from regression equations of Norfloxacin and Tinidazole were 0.03ppm, 0.10ppm and 0.06ppm, 0.19ppm respectively. Regression equation of Tinidazole is = 117845x + 57896, and of Norfloxacin is y = 99753x + 36144. Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.</span></p>