Enregistré dans:
| Auteur principal: | |
|---|---|
| Format: | Recurso digital |
| Langue: | |
| Publié: |
Zenodo
2025
|
| Accès en ligne: | https://doi.org/10.5281/zenodo.16894637 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Table des matières:
- <div> <p><em><span>The<span> </span>main<span> </span>obje<span>c</span>t<span>i</span>ve<span> </span>of<span> </span>t<span>h</span>e<span> </span>p<span>re</span>s<span>e</span>nt<span> </span>stu<span>d</span>y<span> </span><span>w</span><span>a</span>s<span> </span>to<span> </span>f<span>o</span>rmul<span>a</span>te<span> </span><span>a</span>nd<span> </span><span>e</span><span>v</span><span>a</span>luate<span> </span>the<span> </span><span>c</span>ontroll<span>e</span>d r<span>e</span>le<span>a</span><span>s</span>e<span> </span>bu<span>c</span><span>c</span><span>a</span>l tabl<span>e</span>ts <span>o</span>f <span>losartan potassium</span> by using<span> </span>c<span>a</span>rbop<span>o</span>l, HPMC K4M, HPMC K15M<span> </span><span>a</span>nd<span> </span>chitosan<span> </span>w<span>er</span>e<span> </span>s<span>e</span>le<span>c</span><span>t</span><span>e</span>d<span> </span><span>a</span>s<span> </span>bu<span>c</span><span>c</span>o<span>a</span>d<span>h</span><span>e</span>sive<span> </span>po<span>l</span><span>y</span>me<span>r</span>s<span> </span>on<span> </span>the<span> </span>b<span>a</span>sis<span> </span>of<span> </span>their matrix-forming<span> </span>p<span>r</span>op<span>e</span>r<span>t</span>ies. The<span> </span>p<span>re</span><span>p</span><span>a</span>r<span>e</span>d<span> </span>tab<span>l</span><span>e</span>ts<span> </span>w<span>e</span>re<span> </span><span>e</span><span>v</span><span>a</span>luat<span>e</span>d<span> </span>f<span>o</span>r<span> </span>v<span>a</span>rio<span>u</span>s<span> </span>p<span>a</span>r<span>a</span>met<span>e</span>rs<span> </span>such<span> </span><span>a</span>s<span> </span>d<span>r</span>ug<span> </span><span>c</span>ontent,<span> </span>w<span>e</span>i<span>g</span>ht v<span>a</span>ri<span>a</span>t<span>i</span>on, h<span>a</span>rdn<span>e</span>ss, th<span>i</span><span>c</span>kn<span>e</span>ss, f<span>r</span>iabil<span>i</span>t<span>y</span>,<span> </span>sw<span>e</span>l<span>l</span>i<span>n</span>g stud<span>i</span><span>e</span>s,<span> </span>m<span>i</span><span>c</span>ro<span>e</span>nvironm<span>e</span>nt<span> </span>pH, <span><span> </span></span>in<span> </span><span>v</span>i<span>t</span>ro<span> </span>d<span>r</span>ug<span> </span><span>r</span><span>e</span>le<span>a</span>se<span> </span>stud<span>i</span><span>e</span>s,<span> </span>muco<span>a</span>dh<span>e</span>sion str<span>e</span>n<span>g</span>th<span> </span><span>a</span>nd rel<span>ea</span><span>s</span>e<span> ra</span>te<span> </span>kinetics. Based on the evaluation studies, the formulation BL6 has been considered as an optimised formulation, which showed a higher percentage of drug release, 98.47% and it follows zero-order kinetics with diffusion-controlled release.</span></em></p> <p><strong><em><span>Keywords:</span></em></strong><em><span> Losartan potassium, Buccal delivery, Buccoadhesive polymers and Bioadhesion</span></em></p> </div>