Furkejuvvon:
| Váldodahkki: | |
|---|---|
| Materiálatiipa: | Recurso digital |
| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
Zenodo
2020
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| Fáttát: | |
| Liŋkkat: | https://doi.org/10.5281/zenodo.17025416 |
| Fáddágilkorat: |
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Sisdoallologahallan:
- <p>Introduction:<br>From the previous studies, it is quite evident that Ampicillin sodium at a lower dose<br>(40mg/Kg body wt) in wild tropical rodent Funambulus pennanti produces nephrotoxicity by<br>increasing free radical load. This toxicity is limited by pretreatment of melatonin with<br>physiological dose (250μg/kg body wt) in Rattus norvagicus and at higher doses (500μg/kg<br>body wt) in Funambulus pennanti. Recent work indicated that constant light suppressed<br>hydroxyindole-O-methyltransferase (HIOMT) activity and constant dark increased it (Arendt,<br>1995) when HIOMT does not show a definite rhythm in 24 hour light/dark cycle. Further,<br>circadian rhythms in general which are well defined in light-dark cycles persist or free run<br>under CD conditions and are suppressed by constant light (Binkley, 1993). In the night at about<br>2am to 3am is the point when melatonin reaches its peak, and probably due to the increased<br>concentration of melatonin, lipid peroxidation is reduced. Thus, melatonin decreases lipid<br>peroxidation directly and indirectly by stimulating GSH-Px activity. Belanger et al. (1991)<br>reported that the minimal lipid peroxidation level in rat liver tissue was at 01:00 h which the<br>appropriate peak time of melatonin. It may be the increase in melatonin secretion during night<br>responsible for, at least in part, for the nocturnal elevation of total antioxidative status and for<br>the reduction of lipid peroxidation observed in Indian palm squirrel.<br>Considering these data in relation to melatonin and antioxidant systems in kidney,<br>(Pierrefiche and Laborit, 1995) under-took the present research. The main aim was to evaluate<br>the exogenous effects of melatonin and constant dark exposure on antioxidant enzyme activities<br>in renal tissue (TAS% and SOD), oxidative stress lipid peroxidation level (TBARS) with<br>biochemical parameters like acid phosphatase (ACP), alkaline phosphatese (ALP), creatinine<br>and urea in both blood (BUN) and urine to access the functional status of kidney and as a<br>whole the organism.</p>