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| Formato: | Recurso digital |
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Zenodo
2025
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| Subjects: | |
| Acceso en liña: | https://doi.org/10.5281/zenodo.17046490 |
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Table of Contents:
- <p><strong>Background:</strong> Much clinical data suggests that during the COVID-19 pandemic, the number of autoimmune conditions including thyroid disturbances increased.</p> <p><strong>Objective:</strong> Our aim was to assess the incidence of newly diagnosed Graves’ disease (GD) in children before and during the COVID-19 pandemic and its potential association with COVID-19 infection or vaccination.</p> <p><strong>Methods:</strong> A retrospective analysis was performed amongst children aged 0 to 17 years with newly diagnosed GD comparing 2017-2019 and 2020-2022 at a university hospital and regional hospital covering 3 districts in Hong Kong.</p> <p><strong>Results:</strong> Over a 6-year period, 135 children were newly diagnosed with GD. We observed an increased incidence in newly diagnosed GD during the 3 years of the pandemic compared with 3 years prior. The incidence rate of the 3 years before the pandemic was 3.0 per 100 000 person-years (95% CI, 2.2-3.8) and the incidence rate of the 3 years during the pandemic was 4.9 per 100 000 person-years (95% CI, 3.9-6.9). The incidence rate difference was 2.0 per 100 000 person-years (95% CI, 0.65-3.3; P=0.0035). The incidence rate ratio was 1.67 (95% CI, 1.16-2.41; P=0.0035). Prepandemic sex distribution showed 87% female and 13% male; giving a female-to-male ratio of 6.4:1 and during the pandemic, the sex distribution showed 78% female and 22% male; giving a female-to-male ratio of 3.6:1. The mean age of newly diagnosed GD prepandemic was 13.5 ± 2.44 years and during the pandemic mean age was 13.5 ± 2.57 years.</p> <p><strong>Conclusion:</strong> The incidence of newly diagnosed paediatric GD showed an increase during the COVID-19 pandemic compared with prepandemic in Hong Kong. In our study, there is no convincing evidence to suggest that the increase in newly diagnosed GD during the pandemic has association with COVID-19 infection or vaccination within 3 months before the diagnosis of GD.</p> <p><strong>Keywords:</strong> COVID-19; Autoimmune; Paediatric; GD Graves’ disease; SARS-CoV-2</p>