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| Định dạng: | Recurso digital |
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Zenodo
2025
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| Những chủ đề: | |
| Truy cập trực tuyến: | https://doi.org/10.5281/zenodo.17093731 |
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Mục lục:
- <p>This study investigated the dose-dependent toxicological effects of subacute xylene exposure on <br>hepatic, renal, and oxidative stress parameters in Wistar rats. Forty adult male rats were divided <br>into ten groups (n=6). The normal control group (Group 1) received distilled water, while Groups <br>2 to 10 were administered increasing doses of xylene (0.125 to (7 mL/kg) body weight) via oral <br>gavage for 28 days. Significant mortality was observed, with all animals in groups receiving ≥ (3 <br>mL/kg) succumbing before the study concluded, limiting biochemical analysis to Groups 1-5 (0- <br>(1 mL/kg)). Xylene exposure induced severe, dose-dependent hepatotoxicity, evidenced by <br>significant elevation in serum ALT, AST, ALP, and total bilirubin, alongside decreased total <br>protein and albumin. Nephrotoxicity was indicated by increased urea and creatinine levels and a <br>significant disruption in electrolyte and acid-base homeostasis. Mechanistically, a significant <br>depletion of antioxidant enzymes (SOD, CAT, GPx) and a rise in lipid peroxidation (MDA) were <br>observed in both liver and kidney tissues, implicating oxidative stress as a central pathway of <br>toxicity. The results provide evidence that xylene induces multi-organ toxicity primarily through <br>an oxidative mechanism, culminating in organ failure and mortality at higher doses. These findings <br>highlight a substantial occupational health risk and underscore the need for stringent exposure <br>control measures. </p>