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| Format: | Recurso digital |
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Zenodo
2025
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| Dostęp online: | https://doi.org/10.5281/zenodo.17346228 |
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- <p><strong>Background: </strong>Psoriasis is a chronic, immune-mediated inflammatory skin disorder increasingly recognized as a systemic disease. It is associated with metabolic syndrome (Metabolic syndrome) and its components, including obesity, hypertension, dyslipidemia, and hyperglycemia. Early identification of Metabolic syndrome in psoriatic patients is essential to reduce long-term cardiovascular risk. The present study was conducted to evaluate the clinico-epidemiological profile of psoriasis and investigate its association with metabolic syndrome in patients attending a tertiary care hospital.</p> <p><strong>Materials and Methods: </strong>A cross-sectional study was conducted on 100 adult patients with clinically diagnosed psoriasis. Data on demographics, clinical type, and disease severity (PASI score) were collected. Anthropometric measurements, blood pressure, and fasting blood tests (glucose, triglycerides, HDL-C) were performed. Metabolic syndrome was defined according to NCEP ATP III criteria. Statistical analysis included t-tests, Chi-square tests, and Pearson correlation, with <em>p</em> < 0.05 considered significant.</p> <p><strong>Results: </strong>The mean age of patients was 42.5 ± 12.3 years, with a male predominance (60%). Plaque psoriasis was the most common type (70%), and nail involvement was observed in 40% of patients. Metabolic syndrome was present in 38% of patients. Obesity (50%), hypertension (42%), and dyslipidemia (38%) were the most frequent components. Patients with Metabolic syndrome had significantly higher PASI scores than those without Metabolic syndrome (12.8 ± 4.6 vs 8.4 ± 3.2; <em>p</em> < 0.001). PASI scores positively correlated with BMI, waist circumference, blood pressure, fasting glucose, and triglycerides, and negatively with HDL-C.</p> <p><strong>Conclusion: </strong>Psoriasis is frequently associated with metabolic syndrome, especially in patients with severe or extensive disease. Routine screening and management of metabolic risk factors should be integrated into dermatology practice to reduce long-term cardiovascular morbidity and improve patient outcomes</p>