שמור ב:
| Main Authors: | , |
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| פורמט: | Recurso digital |
| שפה: | אנגלית |
| יצא לאור: |
Zenodo
2025
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| נושאים: | |
| גישה מקוונת: | https://doi.org/10.5281/zenodo.17377638 |
| תגים: |
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תוכן הענינים:
- <p>This study evaluated the impact of aqueous leaf extracts from five vegetables—<em>Solanum aethiopicum</em>, <em>Amaranthus hybridus</em>, <em>Pterocarpus mildrsaedii</em>, <em>Ocimum gratissimum</em>, and <em>Telfairia occidentalis</em>—on oxidative stress and endocrine function in male Wistar rats. Fresh leaves were collected from Effurun, Delta State, and processed by air-drying at 30 ± 2°C for two weeks, followed by aqueous extraction (25 g in 250 mL water over 48 h) and freeze-drying. Male rats (125–150 g) were acclimatized for two weeks and then randomly allocated into a control group and five treatment groups. Each treatment group received one extract at three dose levels (100, 200, or 300 mg/kg body weight) via oral gavage every 48 h for 60 days. In control animals, malondialdehyde (MDA) levels averaged 26.55 ± 0.02, while administration of <em>S. aethiopicum</em> reduced MDA to 23.49 ± 0.00 at the low dose, with similar reductions observed for <em>P. mildraedii</em> (23.70 ± 0.01) and <em>T. occidentalis</em> (23.60 ± 0.04). Superoxide dismutase (SOD) activity increased from 3.91 ± 0.03 in controls to 5.85 ± 0.01 with <em>S. aethiopicum</em> at low dose, and catalase (CAT) activity rose from 155.71 ± 0.04 to 164.36 ± 0.02. Glutathione peroxidase (GPx) activity increased from 104.31 ± 0.02 to 120.94 ± 0.10. Hormonal assays revealed that follicle-stimulating hormone (FSH) increased from 2.30 ± 0.02 to 3.10 ± 0.02 and luteinizing hormone (LH) from 0.26 ± 0.04 to 0.43 ± 0.02; notably, <em>T. occidentalis</em> and <em>O. gratissimum</em> elicited the most pronounced endocrine responses. Testosterone levels nearly doubled from 3.87 ± 0.05 to 7.42 ± 0.03 with <em>S. aethiopicum</em>. Statistical analysis confirmed that both dose and extract type significantly influenced these biomarkers (p < 0.05). These findings support the potential use of these plant extracts as natural therapeutic agents in managing oxidative stress and endocrine disorders. </p>