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| Format: | Recurso digital |
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Zenodo
2025
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| Matèries: | |
| Accés en línia: | https://doi.org/10.5281/zenodo.17697448 |
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- <p><span>Nutraceuticals (bioactive food-derived compounds, supplements and functional foods) are widely used as adjuncts for preventing and managing type 2 diabetes (T2D) and for treating prediabetes. Growing clinical and preclinical evidence suggests several nutraceuticals — notably berberine, curcumin (turmeric), vitamin D, probiotics/prebiotics and certain polyphenols — may improve glycemic markers, insulin sensitivity and cardiometabolic risk factors. Evidence quality and consistency vary: some agents show promising randomized-trial data, others mixed or null results, and safety/drug-interaction considerations are important. This article summarizes the current evidence, mechanisms, safety, and practical recommendations. The prevalence of obesity is associated with many health-related problems. Currently, more than 300 million people are considered to be obese. According to the World Health Organization (WHO), by 2030, 87 and 439 million people will be affected in India and the world, respectively. Today, herbal medicines are gaining interest in the treatment of obesity and diabetes, because of their minimal side effects. Gymnemic acid - an active component isolated from Gymnema sylvestre - has anti-obesity and antidiabetic properties, decreases body weight and also inhibits glucose absorption. Several components extracted from Gymnema prevent the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in the circulation. In this paper, an attempt has been made to review the effects of various extracts from Gymnema sylvestre in the regulation of carbohydrate and lipid metabolism in both animal and clinical studies. Lifestyle is the primary prevention of diabetes, especially type-2 diabetes (T2D). Nutritional intake of olive oil (OO), the key Mediterranean diet component has been associated with the prevention and management of many chronic diseases including T2D. Several OO bioactive compounds such as monounsaturated fatty acids, and key biophenols including hydroxytyrosol and oleuropein, have been associated with preventing inflammation and cytokine-induced oxidative damage, glucose lowering, reducing carbohydrate absorption, and increasing insulin sensitivity and related gene expression.</span></p>