محفوظ في:
| المؤلفون الرئيسيون: | , |
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| التنسيق: | Recurso digital |
| اللغة: | |
| منشور في: |
Zenodo
2025
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| الوصول للمادة أونلاين: | https://doi.org/10.5281/zenodo.17737344 |
| الوسوم: |
إضافة وسم
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جدول المحتويات:
- Viral populations, particularly those with RNA genomes, do not exist as single, homogeneous entities but rather as complex distributions of closely related mutant forms, often termed quasispecies. This genetic heterogeneity provides a vast reservoir for adaptation, allowing viruses to rapidly respond to selective pressures and explore diverse evolutionary pathways. Simultaneously, the persistent and dynamic interactions between bacteriophages (phages) and their bacterial hosts represent a powerful coevolutionary arms race. Phages exert immense selective pressure on bacterial populations, driving the evolution of bacterial defense mechanisms suchases CRISPR-Cas systems and restriction-modification systems. In turn, bacteria select for phages capable of overcoming these defenses. This paper posits that the interplay between viral quasispecies dynamics and the relentless selective forces imposed by phage-bacterial coevolutionary arms races serves as a critical, yet underappreciated, driver of viral emergence. We explore how the high mutation rates characteristic of quasispecies, when coupled with the strong selective sweeps and bottlenecks inherent in phage-bacterial interactions, can facilitate the rapid evolution of novel viral phenotypes, including expanded host ranges, increased virulence, or the acquisition of new genetic material. Understanding this intricate ecological and evolutionary nexus is paramount for predicting and mitigating the emergence of new viral threats, especially in environments where bacterial and phage populations are abundant and diverse.