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| Hovedforfatter: | |
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| Format: | Recurso digital |
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| Udgivet: |
Zenodo
2025
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| Online adgang: | https://doi.org/10.5281/zenodo.17876414 |
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Indholdsfortegnelse:
- <p>Aim: To estimate and correlate the levels of lactate dehydrogenase (LDH) as salivary biomarker and nicotine <br>dependence score in smokeless tobacco users with and without gingivitis. <br>Materials and Method: A total of two hundred and twenty two individuals were selected and divided into two <br>different groups in this cross-sectional study and 5 ml of unstimulated saliva was collected by spitting method <br>and sent for biochemical analysis to estimate levels of lactate dehydrogenase. Nicotine dependence score was <br>determined using Fagerstrom Nicotine Dependence Scale – Smokeless Tobacco (FTND-ST). <br>Statistical analysis used: Descriptive statistics, One-way ANOVA and Pearsons correlation. <br>Results: The data presents the mean value of lactate dehydrogenase in test group 1 and test group 2 as <br>380.67±94.84 IU/L and 660.51±181.3 IU/L respectively, which was statistically significant with p value <0.001. <br>LDH levels increased in individuals with gingivitis compared to the periodontally healthy group. The correlation <br>between the parameters lactate dehydrogenase IU/L & Nicotine dependence score showed a good positive <br>correlation and was significant with a p value of <0.001. <br>Conclusions: Salivary LDH and its association with nicotine dependence score could be a prognostic biomarker <br>in identifying the individuals with higher risk at a very early stage. The method being noninvasive, inexpensive, <br>and simple can be used as a screening test and can help in educating patients about the detrimental effects of <br>tobacco.</p>