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| Autore principale: | |
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| Natura: | Recurso digital |
| Lingua: | inglese |
| Pubblicazione: |
Zenodo
2026
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| Soggetti: | |
| Accesso online: | https://doi.org/10.5281/zenodo.18200564 |
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Sommario:
- <p>Drug effectiveness is commonly attributed to molecular properties such as mechanism of action, dose, and target engagement, while timing is treated as a secondary or logistical consideration. This approach implicitly assumes that therapeutic effects are independent of the dynamic state of the system receiving the intervention.</p> <p>This paper reframes drug treatment as a <strong>timing-dependent physiological interaction</strong> between pharmacological input and system regulation. From a systems-level perspective, drug effectiveness emerges from the interaction between the molecule, the regulatory state of the system, and the moment of intervention. Apparent non-response, intolerance, or paradoxical effects may therefore reflect timing mismatch rather than drug inefficacy or toxicity.</p> <p>By viewing timing as a physiological variable rather than a practical constraint, treatment outcomes are interpreted as dynamic processes unfolding over time. Ignoring timing risks turning dynamic disease into static pathology and generates avoidable treatment failure.</p> <p>This work presents a clinical interpretation framework within Dynamic Medicine, emphasizing timing, regulation, and system behavior over isolated molecular effects. No new experimental or clinical data are introduced.</p> <p><em>Conceptual clinical framework; no new experimental or clinical data.</em></p>