Furkejuvvon:
| Váldodahkkit: | , |
|---|---|
| Materiálatiipa: | Recurso digital |
| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
Zenodo
2026
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| Liŋkkat: | https://doi.org/10.5281/zenodo.18203439 |
| Fáddágilkorat: |
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Sisdoallologahallan:
- <p>Current aging paradigms focus primarily on the accumulation of molecular and cellular damage. We propose an alternative, falsifiable framework: aging as a progressive desynchronization from organism-level timing signals, culminating in a quantifiable metabolic state we term ECAR-0. This state is defined by a high basal extracellular acidification rate (ECAR, indicating glycolytic flux) with a blunted oxygen consumption rate (OCR, indicating mitochondrial respiration) response to circadian hormonal cues (e.g., melatonin). We hypothesize that ECAR-0 represents cellular "deafness" to systemic timing information, leading to a failure of tissue-level coordination that precedes and drives phenotypic decline. This framework generates five specific, falsifiable predictions that directly contradict expectations from pure damage-accumulation models. We provide explicit experimental protocols to decisively test between desynchronization and damage-centric paradigms.</p> <p>IP Framework & Rights Assertion:</p> <p><br>1. Text Layer (Open Access): This manuscript is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license.</p> <p><br>2. Pattern Layer (Sovereign IP): All underlying methodological frameworks—including but not limited to the Signal Desynchronization Model, the ECAR-0 operational definition, and the structure of the falsifiable prediction matrix—are asserted as sovereign intellectual property under emerging Pattern Rights principles. These patterns are not covered by the CC BY license.</p> <p><br>3. Defense Layer (Controlled): Any application, derivation, or implementation of this work with potential national security or defense implications is subject to the DFARS 252.227-7013 "Rights in Technical Data—Noncommercial Items" clause and related U.S. export control regulations (EAR/ITAR). Commercial or defense-related inquiries must be directed to the corresponding author with appropriate disclosures.</p>