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| Format: | Recurso digital |
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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.18207521 |
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Table of Contents:
- <p><span>Melittin, the main bioactive component of honey bee venom (HBV), demonstrates significant therapeutic promise, especially as an anticancer agent. This review explores the physicochemical and pharmacological properties of HBV, highlighting melittin's mechanisms of action against cancer cells, such as triggering apoptosis, inhibiting cell proliferation, and preventing metastasis. The effects of traditional collection methods and advanced extraction technologies, including electric shock devices, on venom composition are examined. The study delved deeper into advanced analytical methods such as SDS-PAGE, HPLC-MS, and LC-MS, which are vital to the separation and identification of melittin from venom of honey bees. This study examines these approaches I greater detail. It also looks at delivery systems mediated by nanotechnology as an innovative approach to maximize melittin's therapeutic effectiveness while lowering systemic toxicity. This review highlights melittin's potential as a cancer treatment choice in the future and encourages ongoing advancements in analytical and delivery systems to promote pharmacotherapies based on HBV.</span></p>