Bewaard in:
| Hoofdauteur: | |
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| Formaat: | Recurso digital |
| Taal: | Engels |
| Gepubliceerd in: |
Zenodo
2026
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| Onderwerpen: | |
| Online toegang: | https://doi.org/10.5281/zenodo.18225680 |
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- <p><strong>Abstract</strong></p> <p><strong>Introduction</strong>: The male genital microbiome, particularly in uncircumcised individuals, represents a dynamic ecological niche susceptible to transient dysbiosis. While the sexual transmission of bacterial vaginosis (BV)-associated bacteria is well-documented, the specific temporal and biochemical effects of menstrual fluid exposure on the male sub-preputial environment remain under-characterized.</p> <p><strong>The Hypothesis</strong>: This paper proposes the "Menstrual Inoculation Hypothesis," positing that the introduction of menstrual fluid rich in heme-iron and serum proteins into the anaerobic environment of the sub-preputial space acts as a critical growth agonist for iron-scavenging anaerobes such as Gardnerella vaginalis and Prevotella species. Crucially, this model posits that the mechanism of bacterial entry mirrors the established pathway of HIV transmission in uncircumcised men: rapid mucosal internalization ("absorption") by Langerhans cells and epithelial invasion, rendering surface hygiene ineffective.</p> <p><strong>Evaluation</strong>: Existing literature confirms that the inner foreskin is a mucosal surface rich in HIV-target cells susceptible to rapid viral uptake. This paper argues that G. vaginalis exploits this same anatomical vulnerability via vaginolysin-mediated invasion. The observed failure of immediate post-coital hygiene to prevent subsequent malodor aligns with epidemiological data on HIV, where washing has been shown to be non-protective or detrimental.</p> <p><strong>Conclusion</strong>: This mechanistic framework defines a distinct clinical phenomenon driven by iron availability and anatomical occlusion. The parallel with HIV transmission mechanics suggests that the uncircumcised penis acts as an active, intracellular reservoir for dysbiosis, necessitating prophylactic strategies that go beyond surface surfactants.</p>