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| Main Author: | |
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| Format: | Recurso digital |
| Language: | English |
| Published: |
Zenodo
2022
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| Subjects: | |
| Online Access: | https://doi.org/10.5281/zenodo.18399308 |
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Table of Contents:
- <p>This study provides a detailed investigation into the antiviral potential of 6-mercaptopurine (6-MP) against vaccinia virus <em>in vitro</em>. It demonstrates a potent, dose-dependent inhibition of viral replication, with near-complete suppression achieved at concentrations of 1.0–1.5 µg/mL, while host cell viability remains high. Mechanistic analysis reveals that 6-MP disrupts the viral life cycle by depleting purine nucleotide pools, leading to severe impairment of both viral DNA synthesis and late protein production. The findings establish a clear therapeutic window and confirm the vulnerability of large DNA viruses to host-directed metabolic inhibition, supporting the rationale for exploring purine synthesis inhibitors as broad-spectrum antivirals.</p>