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| Format: | Recurso digital |
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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.18519964 |
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Table of Contents:
- <p>This infographic provides a <strong>comprehensive overview of uric acid metabolism and gout progression</strong>, highlighting the <strong>characteristics and treatment strategies at each stage</strong>. It includes:</p> <ol> <li> <p><strong>Core Concept:</strong> Uric acid as the final waste product of purine metabolism via xanthine oxidase, with no physiologic function; blood levels reflect the balance of production and elimination.</p> </li> <li> <p><strong>Uric Acid Production (Synthesis):</strong></p> <ul> <li> <p><strong>External sources:</strong> Dietary purines (red meat, organ meat, seafood) as potential triggers.</p> </li> <li> <p><strong>Internal sources:</strong> De novo purine synthesis in the liver (DNA, RNA, ATP/GTP production), alcohol, and DNA/RNA breakdown (cell turnover), with chronic and acute triggers like cancer, chemotherapy, trauma, surgery, and infection.</p> </li> </ul> </li> <li> <p><strong>Uric Acid Elimination:</strong></p> <ul> <li> <p><strong>Kidneys:</strong> Responsible for 2/3 of uric acid excretion; filtration, reabsorption, secretion. Factors reducing elimination include CKD, dehydration, and certain drugs (thiazides, loop diuretics, niacin, etc.).</p> </li> <li> <p><strong>GI Tract:</strong> Accounts for 1/3 of uric acid elimination via normal gut flora.</p> </li> </ul> </li> <li> <p><strong>Four Stages of Gout Pathophysiology:</strong></p> <ul> <li> <p><strong>Step 1 – Hyperuricemia:</strong> Asymptomatic; no treatment.</p> </li> <li> <p><strong>Step 2 – Asymptomatic Crystal Deposition:</strong> MSU crystals in synovial fluid; still no treatment.</p> </li> <li> <p><strong>Step 3 – Acute Gout Attack:</strong> Monoarticular arthritis (podagra), inflammation via IL-1 and neutrophils; treated with anti-inflammatory drugs (NSAIDs, colchicine, corticosteroids).</p> </li> <li> <p><strong>Step 4 – Chronic / Advanced Gout:</strong> Tophi, kidney stones, carpal tunnel; treated with urate-lowering therapy (xanthine oxidase inhibitors, uricosurics).</p> </li> </ul> </li> </ol> <p>The infographic uses <strong>arrows and flowcharts</strong> to illustrate production vs. elimination, with <strong>icons for food, liver, DNA/RNA, kidney, gut flora, drugs, alcohol, stress/surgery</strong>, and highlights <strong>causes vs. triggers</strong> for clarity. Designed for <strong>medical students and healthcare professionals</strong>, it provides a <strong>stepwise, visual understanding of uric acid metabolism and gout progression</strong>, including <strong>stage characteristics and treatment strategies</strong>.</p>