保存先:
| 第一著者: | |
|---|---|
| フォーマット: | Recurso digital |
| 言語: | 英語 |
| 出版事項: |
Zenodo
2026
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| オンライン･アクセス: | https://doi.org/10.5281/zenodo.18811608 |
| タグ: |
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目次:
- <p><span>In situ gel drug delivery systems have attracted considerable interest in recent years due to their ability to provide sustained drug release, enhanced bioavailability, prolonged gastric residence time, and improved patient compliance. The present study was aimed at performing preformulation characterization and drug–excipient compatibility evaluation of Ranolazine for its application in gastro-retentive in situ gel formulation. Preformulation studies including organoleptic evaluation, pH determination, melting point analysis, and solubility studies were conducted to assess the physicochemical properties of the drug. Ranolazine exhibited a near-neutral pH, indicating good aqueous stability. The melting point analysis confirmed the crystalline nature and purity of the drug sample. Solubility studies revealed that Ranolazine was freely soluble in methanol, soluble in ethanol, sparingly soluble in acetone, and slightly soluble in distilled water, highlighting the need for formulation strategies to improve aqueous solubility.</span></p>