Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Recurso digital |
| Kieli: | |
| Julkaistu: |
Zenodo
2026
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| Linkit: | https://doi.org/10.5281/zenodo.19097161 |
| Tagit: |
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Sisällysluettelo:
- <p>Two respiratory stimuli were implemented: a hypercapnic stimulus and a hyperoxic stimulus. The hypercapnic stimulus consisted of three 60 s blocks of hypercapnia (5% CO<sub>2</sub>, 21% O<sub>2</sub>, 74% N<sub>2</sub>) interleaved with four 60 s blocks of normocapnia (medical air: 21% O<sub>2</sub>, 79% N<sub>2</sub>) to give a total duration of 7 minutes. The hyperoxia stimulus had two repeats of the following block: 120 s normocapnia, 30 s hyperoxia (100% O<sub>2</sub>) and 90 s with both normoxic and hyperoxic gases flowing simultaneously (equivalent to 60.5% O<sub>2</sub>, 39.5% N<sub>2</sub>). This block was repeated twice and followed by a further 120 s normocapnic period to give a total duration of 10 minutes. The initial 30 s 100% oxygen block was implemented to produce a large oxygen gradient between the alveolar gas and the blood and results in a rapid increase in end tidal partial pressure of oxygen (PetO<sub>2</sub>). The switch to 60.5% oxygen then rapidly reaches a plateau for the remainder of the block. Each of the medical flow meters were set to 15 lpm which resulted in a total flow of 30 lpm during the plateau of the hyperoxia stimulus. </p> <p>Expired gases were measured (O<sub>2</sub> and CO<sub>2</sub>) using a respiratory gas analyser (ML206, AD Instruments, Dunedin, New Zealand).</p>