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| Médium: | Recurso digital |
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Zenodo
2026
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| On-line přístup: | https://doi.org/10.5281/zenodo.19097247 |
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- <p>Orodispersible Fil.ms (ODFs) or Orodisp.ersible Str.ips (ODSs) are a maj.or emer.ging form of new rou.te to drug deli.very (No.vel Drug Deli.very Syst.ems or NDDS). Such dos.es are ultra.-thin sin.gle or multi.layer she.ets of spec.ial mater.ials. They are mea.nt to rele.ase the drug (ac.tive pharmaceutical ingre.dient or API) rapi.dly upon contacting sal.iva in the mou.th [1]. ODFs abs.orb wat.er fast and diss.olve to form a thin liq.uid or mixt.ure that can be swall.owed by the pati.ent without requi.ring wat.er or need.ing to chew [2]. This techn.ology addre.sses a signif.icant iss.ue kno.wn as dysph.agia (the inabi.lity to swal.low) and assi.sts dru.gs to perf.orm the.ir job bet.ter by enhan.cing the quan.tity of medi.cine the body absorbs (bioavai.lability). ODFs are not only impor.tant in mak.ing thi.ngs eas.ier. Thro.ugh the abun.dant blo.od sup.ply in the mou.th, and due to the fact that the mou.th has low concent.rations of chem.ical act.ion that destroys dru.gs, the medic.ation can byp.ass the fir.st sta.ge of metab.olism (hep.atic first.-pass metab.olism) in the liv.er. This enha.nced rou.te ensu.res that smal.ler amou.nts of drug wou.ld be requ.ired (dose reduc.tion) and that the drug wou.ld have a rapid act.ion eff.ect, and ODFs wou.ld be ide.al in cas.es whe.re a qui.ck act.ion is requ.ired such as in cas.es of an emerg.ency. The techn.ology has been appl.ied prima.rily in the deli.very of pot.ent dru.gs that are usua.lly in a sma.ll dose and in assis.ting drugs whi.ch are not read.ily solu.ble (seen as BCS Cla.ss II and Cla.ss IV in the pharmac.eutical commu.nity) absorb better</p>