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| Autore principale: | |
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| Natura: | Recurso digital |
| Lingua: | polacco |
| Pubblicazione: |
Zenodo
2026
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| Soggetti: | |
| Accesso online: | https://doi.org/10.5281/zenodo.19225767 |
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Sommario:
- <p dir="ltr">While the high polygenic architecture of Attention Deficit Hyperactivity Disorder (ADHD) is well documented, the systemic family environments generated by parents with high genetic risk (genetic nurture) remain underexplored. In families with a high genetic load for ADHD, unacknowledged parental compensatory strategies, such as compulsive overactivity, hyper scheduling, and intolerance of idleness, often crystallize into rigid family norms.</p> <p dir="ltr">This working paper outlines a pilot study protocol designed to investigate a paradoxical clinical phenomenon observed in systemic family therapy: the "white sheep" effect. We hypothesize that in high ADHD risk families, the sibling with a lower Polygenic Risk Score (PRS) for ADHD experiences a profound person environment mismatch. Consequently, this genetically "healthier" sibling will exhibit lower life satisfaction and higher internalizing symptoms (for example internalized shame, depression) compared to their higher PRS sibling, due to a fundamental neurobiological discordance with the family compensatory baseline.</p> <p dir="ltr">Utilizing a within sibling difference design (N = 50 to 80 pairs) and genome wide genotyping (Illumina Global Screening Array), the study inherently controls for passive gene environment correlation to isolate the psychological impact of this polygenic discordance. By integrating behavioral genetics with systemic psychotherapy, this project proposes a novel mechanism of psychopathology: suffering not as a direct result of risk alleles, but as a consequence of genetic environmental mismatch.</p>