Salvato in:
| Autore principale: | |
|---|---|
| Natura: | Recurso digital |
| Lingua: | inglese |
| Pubblicazione: |
Zenodo
2026
|
| Accesso online: | https://doi.org/10.5281/zenodo.19414972 |
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Sommario:
- <p><span>The<span> </span>purpose<span> </span>of<span> </span>this<span> </span>review<span> </span>is to<span> </span>explore<span> </span>the<span> </span>difficulties<span> </span>in penetration<span> </span>of<span> </span>drug<span> </span>across<span> </span>nail<span> </span><span>plate </span>& enhancement of bioavaibillity of antifungal drug. Nail drug delivery systems face significant challenges due to the nail plate's inherent barrier properties, hindering effective treatment of conditions like onychomycosis and psoriasis. Conventional topical treatments often yield unsatisfactory<span> </span>results,<span> </span>emphasizing<span> </span>the<span> </span>need<span> </span>for<span> </span>innovative<span> </span>strategies<span> </span>to<span> </span>enhance<span> </span>drug<span> </span>penetration. This review explores recent advancements in nail drug delivery, including chemical method such as Keratolytic enhancers, physical method techniques such as microneedles and Laser ultraviolet light,<span> </span>mechanical<span> </span>method<span> </span>such<span> </span>as<span> </span>nail<span> </span>avulsion,<span> </span>Nail<span> </span>abrasion<span> </span>and<span> </span>novel<span> </span>drug<span> </span>formulations<span> </span>like<span> </span>nail lacquers<span> </span>and<span> </span>nanoparticles.<span> </span>By<span> </span>overcoming<span> </span>the<span> </span>challenges<span> </span>of<span> </span>nail<span> </span>drug<span> </span>delivery,<span> </span>these<span> </span>innovations hold promise for improving </span>treatment efficacy and patient outcomes, ultimately enhancing the management<span> </span>of<span> </span>nail<span> </span>disorders.<span> </span>This<span> </span>systemic<span> </span>review<span> </span>covers<span> </span>the<span> </span>anatomy<span> </span>of a<span> </span>human<span> </span>nail,<span> </span>diseases related to nail plate, the formulations designed for nail application and some techniques used to enhance<span> </span>the<span> </span>topical<span> </span>bioavailability<span> </span>of<span> </span>the<span> </span>drugs<span> </span>across<span> </span>the<span> </span>nail,<span> </span>latest<span> </span>trends<span> </span>in<span> </span>drug<span> </span>delivery<span> </span>across the nail.</p>