Kaydedildi:
| Yazar: | |
|---|---|
| Materyal Türü: | Recurso digital |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
Zenodo
2026
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| Konular: | |
| Online Erişim: | https://doi.org/10.5281/zenodo.19617145 |
| Etiketler: |
Etiketle
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İçindekiler:
- <p class="p1">Cancer diagnosis, especially in stage IV, constitutes a classic example of inescapable stress that suppresses anti-tumor immunity and worsens prognosis. Building on the 1982 Visintainer–Seligman experiment demonstrating superior tumor rejection under escapable versus inescapable stress, I propose an integrated psycho-oncology approach that transforms perceived lack of control into objective mastery. In patients with ultrasonographically visible solid tumors, real-time color-Doppler ultrasonography is combined with injection of macrophage-activating agents (<em>e.g</em>. sargramostim/GM-CSF or mifamurtide). Activated macrophages produce nitric oxide, inducing measurable peri-tumoral vasodilation visible within 24–96 hours. Patients observe this immune activation directly on a large screen while the operator explains the images, creating a powerful, multisensory biofeedback experience. Pre- and post-treatment videos become a personal “switch” that patients recall during moments of stress, reinforcing the shift from inescapable to escapable stress. The method rests on three decades of research on CSF-1/c-fms signaling and transcranial/soft-tissue ultrasonography. By linking psychological control to a tangible physiologic event, this low-cost, non-invasive strategy simultaneously reduces cancer-related distress and potentiates anti-tumor immunity. Formal prospective trials are warranted to validate its clinical impact.</p>