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Main Authors:	Parankusham, Harthik, Vanderlip, Casey, Birkenbihl, Colin Jan, Krishna, Eashwar, Ugboaja, Chizobam, Budson, Andrew, Frank, Brandon
Format:	Recurso digital
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Published:	Zenodo 2026
Subjects:	Alzheimer's disease plasma biomarkers p-tau217 amyloid PET machine learning clinical decision support diagnostic gray zone
Online Access:	https://doi.org/10.5281/zenodo.19639295
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Table of Contents:

Two-stage diagnostic algorithm (Gatekeeper-Reflex for Alzheimer's Diagnostics) that resolves diagnostic uncertainty in plasma p-tau217 testing by combining a univariate logistic regression screen with a multi-marker random forest classifier for gray zone cases.