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| Main Authors: | , |
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| Formato: | Recurso digital |
| Idioma: | inglês |
| Publicado em: |
Zenodo
2026
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| Assuntos: | |
| Acesso em linha: | https://doi.org/10.5281/zenodo.19667332 |
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Sumário:
- <p class="MsoNormal"><span>The integration of traditional botanical knowledge with modern scientific and technological tools has become a major driver of innovation in contemporary life sciences. The genus <em>Barleria </em>L. (family Acanthaceae) exemplifies this convergence by combining taxonomic diversity, chemical complexity, and emerging technological applications in drug discovery. Distributed mainly across Africa, the Indian subcontinent, and Southeast Asia, <em>Barleria</em> comprises approximately 250–300 species with wide ecological adaptability and long-standing ethnomedicinal relevance (Balkwill & Balkwill, 1998; Darbyshire et al., 2010; McDade et al., 2018).</span></p> <p class="MsoNormal"><span>Recent advances in phytochemistry, mechanistic pharmacology, and computational biology have revealed a rich repertoire of bioactive secondary metabolites, including iridoid glycosides, flavonoids, and terpenoids, with demonstrated anti-inflammatory, antimicrobial, antidiabetic, and hepatoprotective activities (Bawake & Gaykar, 2022). Computational approaches such as molecular docking, molecular dynamics simulations, and in silico ADMET prediction have accelerated lead identification and improved mechanistic understanding, highlighting the genus as a promising source of phytopharmaceutical candidates (Li et al., 2022; Patel et al., 2024).</span></p> <p class="MsoNormal"><span>Despite strong preclinical evidence, translational challenges persist, particularly in standardization, pharmacokinetic validation, and clinical evaluation. This manuscript presents <em>Barleria</em> as an innovative botanical model, illustrating how interdisciplinary integration of taxonomy, chemistry, pharmacology, and digital technologies can contribute to future science- and technology-driven therapeutic development.</span></p>