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| Autore principale: | |
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| Natura: | Recurso digital |
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| Pubblicazione: |
Zenodo
2026
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| Soggetti: | |
| Accesso online: | https://doi.org/10.5281/zenodo.19684292 |
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Sommario:
- <p class="MsoNormal"><span>Non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac sodium are widely used for the management of pain and inflammation; however, their chronic use is associated with gastrointestinal (GI) complications, including ulceration and bleeding. Pantoprazole sodium, a proton pump inhibitor (PPI), is commonly co-administered to mitigate NSAID-induced gastric damage. The present study aims to develop and evaluate a bilayer tablet system comprising an immediate release (IR) layer of pantoprazole sodium and a sustained release (SR) layer of diclofenac sodium to enhance therapeutic efficacy while minimizing adverse effects. Bilayer tablet technology offers a promising approach for the sequential delivery of drugs with different release profiles. In this investigation, the IR layer was formulated using superdisintegrants such as crospovidone to achieve rapid drug release, whereas the SR layer was developed using hydrophilic polymers like hydroxypropyl methylcellulose (HPMC) to control drug release over an extended period. Preformulation studies including compatibility analysis (FTIR), flow properties, and compressibility were performed to ensure suitability of excipients. The tablets were prepared using a direct compression technique. The developed formulations will be evaluated for physicochemical parameters, including hardness, friability, weight variation, drug content, and in vitro dissolution behavior. The anticipated outcome is a bilayer tablet that provides immediate gastric protection followed by prolonged anti-inflammatory action, thereby improving patient compliance and therapeutic outcomes.</span></p>