Gorde:
| Egile Nagusiak: | , , , |
|---|---|
| Formatua: | Recurso digital |
| Hizkuntza: | ingelesa |
| Argitaratua: |
Zenodo
2026
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| Gaiak: | |
| Sarrera elektronikoa: | https://doi.org/10.5281/zenodo.19726757 |
| Etiketak: |
Etiketa erantsi
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Aurkibidea:
- <p class="MsoNormal"><span>Epithelia likely predate the last common animal ancestor, yet the evolutionary origin and nutritional regulation of epithelial remodelling remain poorly understood. Here, we show that extensive, starvation-induced cell loss in the sea anemone <em>Nematostella vectensis</em> is associated with epidermal cell extrusion. This process involves formation of a rosette-like arrangement in which an apoptotic, extruding cell is surrounded by a phospho-ERK1/2-positive ring of cells, accompanied by basal translocation of adherens junction components. Combining chemical perturbations with computational quantification of extrusion and cell density, we show that apoptosis is necessary but not sufficient for rosette formation, and that ERK1/2 signalling limits epidermal extrusion density. Furthermore, we find </span><span>increased </span><span>extrusion activity during starvation, and </span><span>potential</span> <span>nutrient recycling </span><span>via phagocytosis </span><span>of extruded cells</span><span>. Together, our findings indicate that epithelial cell extrusion has physiological roles in sea anemones and that its key hallmarks are likely evolutionarily ancient, predating the last common </span><span>cnidarian-bilaterian </span><span>ancestor.</span></p> <p class="MsoNormal"><span>This repository contains the rosette identification training dataset, generated through manual annotation of previously segmented images. These annotations were used to train an automated rosette identification model for application across the full dataset.</span></p>