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| Materyal Türü: | Recurso digital |
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Zenodo
2026
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| Konular: | |
| Online Erişim: | https://doi.org/10.5281/zenodo.19833272 |
| Etiketler: |
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İçindekiler:
- Berberine activates AMPK through LKB1 phosphorylation, leading to mTOR inhibition and ULK1 activation. This enhances astrocyte-specific autophagy flux, promoting clearance of misfolded GFAP aggregates and Rosenthal fibers. Additionally, berberine modulates TFEB nuclear translocation to upregulate lysosomal biogenesis genes.