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Bibliographic Details
Main Authors: Smith, John Richard, SHAI / HATI3
Format: Recurso digital
Language:English
Published: Zenodo 2026
Subjects:
Alzheimer's disease; neurodegeneration; coupled regulatory domains; longitudinal intervention; bifurcation points; sex differences; menopause; APOE4; glymphatic; preventive neurology; brain longevity
Online Access:https://doi.org/10.5281/zenodo.19918439
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Table of Contents:
  • <p><span>Description / Abstract:</span></p> <p> </p> <p><span>Clinical translation document presenting a unified temporal architecture for Alzheimer's disease as a longitudinal regulatory failure across ten coupled domains. Identifies four bifurcation points (Aβ clearance crossover, menopause regime shift, CAA trap engagement, BBB collapse), proposes sex-differentiated intervention timing, and maps a longitudinal adaptive intervention methodology from validated developmental services practice. This version is prepared for clinical audience accessibility — domain specialists in preventive neurology, gerontology, and related fields. Companion to the primary SIP-NEURO-LONG-01 record which contains the full theoretical formalism.</span></p>

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