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| Format: | Recurso digital |
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Zenodo
2026
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| Matèries: | |
| Accés en línia: | https://doi.org/10.5281/zenodo.19919627 |
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- <p class="MsoNormal"><span>Magnetic microspheres are polymer-based particulate carrier systems incorporating magnetic materials that respond to external magnetic fields, enabling site-specific drug delivery. These microspheres typically range from 1 to 1000 µm in size and are designed to enhance therapeutic efficacy while minimizing systemic toxicity. Magnetic targeting involves encapsulating or conjugating drugs within magnetically responsive carriers that can be guided and retained at the target site using an external magnetic field. This review provides a comprehensive overview of magnetic microspheres, including their principles of drug targeting, magnetic properties, advantages and limitations, and classification into therapeutic and diagnostic systems. Various preparation methods such as solvent evaporation, multiple emulsion, phase separation, hot melt microencapsulation, dispersion copolymerization, and microwave-assisted techniques are discussed in detail. Additionally, characterization and evaluation parameters including particle size, surface morphology, swelling index, flow properties, surface charge, drug release behaviour, and entrapment efficiency are described. The diverse biomedical applications of magnetic microspheres in targeted drug delivery, cancer therapy, hyperthermia, biomolecule separation, diagnostics, and biotechnology highlight their significant potential as advanced drug delivery systems.</span></p>