Guardat en:
| Autors principals: | , , , , , |
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| Format: | Recurso digital |
| Idioma: | anglès |
| Publicat: |
Zenodo
2026
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| Matèries: | |
| Accés en línia: | https://doi.org/10.5281/zenodo.19923526 |
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- <p class="MsoNormal"><span>The neurodevelopmental illness known as autism spectrum disorder (ASD) has a complex etiology. Vitamin/mineral and targeted vitamin therapy trials have been prompted by the numerous reports of nutritional deficiencies and altered metabolism (oxidative stress, methylation abnormalities, immunological dysregulation) in ASD. Goal: Examine clinical data on vitamin-based and multivitamin therapy for core and related symptoms of ASD, summarizing safety, mechanisms, and suggestions for study and practice. Methods: Narrative evidence synthesis with a focus on large observational studies, systematic reviews/meta-analyses, and randomized controlled trials (RCTs). Results: Following multivitamin or tailored vitamin therapy (e.g., folinic acid, methyl cobalamin, vitamin D), small RCTs and a number of mechanistic and cohort studies indicate improvements in metabolic biomarkers and, in certain trials, clinician-rated or parent-reported symptoms.</span><span> </span><span>In observational studies and meta-analyses, prenatal folic acid/multivitamin consumption is consistently linked to a lower child risk of ASD. The overall quality of the data is inconsistent: there aren't many big, long-term RCTs, and conclusions can't be drawn with certainty because to differences in populations, supplements, dosage, and outcome measures. At conventional dosages, safety statistics are typically positive; nevertheless, large doses (or imbalanced supplements) have potential and actual dangers that need to be monitored.</span></p>