Saved in:
| Hovedforfatter: | |
|---|---|
| Format: | Recurso digital |
| Sprog: | engelsk |
| Udgivet: |
Zenodo
2026
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| Fag: | |
| Online adgang: | https://doi.org/10.5281/zenodo.19968131 |
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Indholdsfortegnelse:
- <p>This study evaluates whether gene expression dispersion (coefficient of variation, CV) represents a true survival signal or a projection artifact in high-dimensional transcriptomic data. In TCGA glioblastoma, CV stratifies survival; however, falsification through random gene controls, permutation testing, and cross-cancer analysis demonstrates that the signal is not robust or generalizable. Principal component analysis (PCA) substantially outperforms CV in survival prediction, and CV becomes non-significant when PCA is included. Correlation analysis shows that CV partially overlaps with latent structure, indicating that it represents a degraded projection. Enrichment analysis identifies a biologically coherent axis separating metabolic transport processes from extracellular matrix and angiogenic remodeling. These findings demonstrate that dispersion-based survival signals arise from structured biological programs rather than independent statistical mechanisms.</p>