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| Natura: | Recurso digital |
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Zenodo
2026
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| Accesso online: | https://doi.org/10.5281/zenodo.20000878 |
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Sommario:
- Two novel Zn(II) complexes derived from 6-aminobenzothiazole-based Schiff base ligands (HL1 and HL2) were synthesized and comprehensively characterized using spectroscopic and analytical techniques, including mass spectrometry, FT-IR, UV–Vis spectroscopy and thermogravimetric analysis (TGA). The complexes, formulated as [Zn(HL)₂(H₂O)₂], were found to exhibit a six-coordinate octahedral geometry. DNA-binding studies, carried out using electronic absorption and fluorescence spectroscopy, indicated an intercalative mode of interaction, with binding affinities following the order 1a > 2a. The complexes also demonstrated efficient DNA cleavage activity under oxidative and photolytic conditions, showing greater efficacy than the free ligands. In vitro cytotoxicity studies against A549 (lung cancer) and MCF-7 (breast cancer) cell lines revealed enhanced anticancer activity for the Zn(II) complexes. Furthermore, antimicrobial investigations confirmed that the metal complexes possess superior activity compared to their parent ligands.