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| Format: | Recurso digital |
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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.20002057 |
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Table of Contents:
- <p class="MsoNormal"><span>Aceclofenac is a widely used non-steroidal anti-inflammatory drug for the management of chronic inflammatory and painful conditions; however, its conventional oral administration is often associated with gastrointestinal side effects and fluctuating plasma drug levels. Transdermal drug delivery systems have emerged as a promising alternative by providing controlled and sustained drug release while bypassing first-pass metabolism and improving patient compliance. The development of Aceclofenac transdermal patches requires careful consideration of formulation variables, including polymer selection, permeation enhancers, patch design, and release control strategies. This review comprehensively discusses advanced formulation strategies employed in the development of Aceclofenac transdermal patches, with particular emphasis on the role of synthetic and natural polymers, chemical and natural permeation enhancers, matrix and reservoir-type systems, and controlled and targeted release approaches. Recent advances in nanocarrier-based systems, physical enhancement techniques, and targeted transdermal delivery have also been highlighted. In addition, critical evaluation parameters, recent research trends, patent landscape, formulation challenges, and regulatory considerations are systematically reviewed. Overall, the findings suggest that optimized polymer matrices combined with suitable permeation enhancers can significantly improve the transdermal delivery of Aceclofenac, offering sustained therapeutic efficacy with reduced systemic side effects. The review provides valuable insights into current progress and future prospects of Aceclofenac transdermal patches, supporting their potential as an effective and patient-friendly alternative to conventional oral therapy.</span></p>