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| Format: | Recurso digital |
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Zenodo
2026
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| Online-Zugang: | https://doi.org/10.5281/zenodo.20061312 |
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Inhaltsangabe:
- <p class="MsoNormal"><span>Background: Gastroprotective disorders including peptic ulcer disease, gastritis, and gastroesophageal reflux disease (GERD) remain a major global health burden, affecting millions of individuals annually. Conventional pharmacological agents such as proton pump inhibitors, while effective, are associated with significant long-term adverse effects. Herbal formulations provide a safer, patient-friendly alternative with multi-targeted pharmacological actions. Objective: This study aimed to develop, characterize, and evaluate a novel herbal syrup formulation containing standardized extracts of Glycyrrhiza glabra (licorice root), Aloe vera, Zingiber officinale (ginger), Emblica officinalis (amla), and Curcuma longa (turmeric) for gastroprotective activity. Methods: Herbal extracts were prepared by maceration. The syrup was formulated using sucrose as the base vehicle with appropriate preservatives, buffering agents, viscosity modifiers, and flavoring agents. Physicochemical characterization included pH, specific gravity, viscosity, drug content, and microbial load assessments. In vivo gastroprotective activity was evaluated using the ethanol-induced gastric ulcer model in Wistar albino rats. Results: The herbal syrup displayed pH 4.8 ± 0.12, specific gravity 1.24 ± 0.03 g/mL, viscosity 320 ± 18 cP, and drug content 98.6 ± 1.2%. In vivo studies demonstrated maximum ulcer protection of 79.7% at the high dose, closely comparable to omeprazole (80.5%). Biochemical analysis revealed significant restoration of antioxidant enzymes and gastric mucus content. Stability at accelerated conditions (40 degrees Celsius/75% RH for 3 months) was satisfactory. Discussion: The synergistic action of the phytoconstituents — glycyrrhizin, acemannan, gingerols, tannins, and curcuminoids — mediates gastric mucosal protection through antioxidant activity, mucus secretion enhancement, anti-inflammatory cytokine modulation, and acid suppression. Conclusion: The developed herbal syrup exhibited promising gastroprotective activity </span><span>comparable to the standard drug, with excellent physicochemical properties, safety profile, and stability, supporting its potential as a natural therapeutic agent for managing gastric disorders.</span></p>