Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Recurso digital |
| Sprache: | Englisch |
| Veröffentlicht: |
Zenodo
2026
|
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.5281/zenodo.20071614 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Inhaltsangabe:
- <p>I propose and formalize the Gut–Enteric–Cortical Cascade as a field-theoretic framework connecting gut microbiota composition to cortical criticality in the near-critical regime (RC³). The gut microbiota is formalized as the upstream boundary condition of the enteric field Ψ(x,t), which modulates the cortical field Φ(x,t) via the vagally-mediated cascade:</p> <p>M → μ_eff[M] → Ψ → ⟨Ψ⟩_vagal → λ_eff[Ψ] → Φ</p> <p>where M is functional microbial diversity, μ_eff and λ_eff are the enteric and cortical control parameters respectively, and β is the ENS–cortical coupling coefficient estimated via HF-HRV × PCI covariation.</p> <p>The framework generates 17 falsifiable experimental predictions, a multimodal proxy calibration framework for the coupling coefficients α and β (Table 1), and a novel epidemiological hypothesis linking dietary transition velocity to RC³/ADHD prevalence at population scale.</p> <p>A unified mapping of cascade components, experimental proxies, and predictions is provided in Table 1. Extended material — including the RC³ Modulator Classification Matrix, the RC³-Diet standardized protocol, the institutional landscape analysis, and the exploratory ecological analysis — is available in the Supplementary Material (DOI: [insertar DOI suplemento]).</p> <p>This preprint is part of the CIFT series (Papers I–XII). Related work: Papers I–XI available at https://zenodo.org/search?q=CIFT+Stjepovic</p> <p>Target journal: Frontiers in Neuroscience (Hypothesis & Theory) | Scientific Reports (Nature)</p>