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| Format: | Recurso digital |
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Zenodo
2026
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| Online-Zugang: | https://doi.org/10.5281/zenodo.20091295 |
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Inhaltsangabe:
- <p>The Sugar-Iron Bomb framework proposes a multi-layer mechanistic model linking metabolic dysfunction, hemolysis, macrophage iron dysregulation, and oxidative genomic instability to carcinogenesis.</p> <p>The framework centers on the hypothesis that chronic metabolic and inflammatory stress can destabilize erythrocyte integrity, producing sustained hemolysis and progressive exhaustion of systemic hemoglobin-buffering systems.</p> <p>Within macrophage-rich tissues and tumor microenvironments, excessive hemoglobin and heme processing may overload the CD163-HO-1 iron-handling axis, generating expansion of the labile iron pool and localized oxidative stress through Fenton chemistry.</p> <p>The framework proposes that this iron-driven oxidative microenvironment contributes to DNA damage, genomic instability, inflammatory amplification, and progressive tumor evolution.</p> <p>This document defines the Core Canon of the Sugar-Iron Bomb framework, the foundational mechanistic architecture considered central to the current model.</p>