Gorde:
| Egile Nagusiak: | , , , , , , , , , , |
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| Formatua: | Recurso digital |
| Hizkuntza: | |
| Argitaratua: |
Zenodo
2026
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| Gaiak: | |
| Sarrera elektronikoa: | https://doi.org/10.5281/zenodo.20098974 |
| Etiketak: |
Etiketa erantsi
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Aurkibidea:
- PURPOSE: In 1996, Ciucci et al. characterized the lymphatic anatomy of 250 upper limbs of fetal cadavers. They described the presence of a lymphatic channel in the palmar skin that spanned the first interdigital space and anastomosed with the lymphatic collaterals on the dorsal surface of the hand. This palmar lymphatic channel (a pathway we have named the Ciucci pathway) has yet to be described with in-vivo imaging. As the Ciucci pathway is a superficial-to-deep lymphatic communication, and therefore a potential protective factor against breast cancer-related lymphedema (BCRL), we investigated our ability to image this pathway with indocyanine green (ICG) lymphography. METHODS: Healthy female volunteer and female breast cancer survivors without a history of BCRL at least two years after axillary lymph node dissection (ALND) underwent lymphatic mapping of the upper extremities with ICG lymphography. ICG was injected in six standard sites in the hand/wrist and upper arm. The presence of the Ciucci pathway was recorded and compared between cohorts with Fisher's exact test. RESULTS: 110 arms of 55 healthy volunteers and 31 at-risk arms of 31 breast cancer survivors without BCRL were included. The Ciucci pathway was present in one of 110 (0.9%) healthy female volunteer arms and present in five of 31 (16.1%) at-risk arms of breast cancer survivors (p = 0.002). CONCLUSION: The Ciucci pathway was more frequently observed in the at-risk arms of volunteers with a history of ALND without BCRL than in the arms of healthy female volunteers. This may suggest that this superficial-to-deep lymphatic connection functions as a protective pathway for those at risk of developing BCRL. *Source: https://ps-rc.org/meeting/Program/2026/EP85.cgi*