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| Hlavní autor: | |
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| Médium: | Recurso digital |
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Zenodo
2026
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| Témata: | |
| On-line přístup: | https://doi.org/10.5281/zenodo.20132105 |
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- <p><span>Cancer remains one of the leading causes of morbidity and mortality worldwide despite continuous advances in diagnosis and treatment. Conventional therapies such as chemotherapy, radiotherapy, and surgery are often limited by systemic toxicity, poor selectivity, multidrug resistance, recurrence, and damage to healthy tissues. In recent years, nanotechnology has emerged as a transformative strategy in oncology by enabling site-specific drug delivery and multifunctional therapeutic systems. Among different nanocarriers, magnetic nanoparticles (MNPs) have gained considerable attention because of their unique responsiveness to external magnetic fields, high surface area, tunable physicochemical properties, and theranostic potential. These nanoparticles can be magnetically guided toward tumor tissues, improving local drug concentration while minimizing off-target toxicity. In addition to targeted chemotherapy, magnetic nanoparticles are widely explored for magnetic hyperthermia, imaging enhancement, gene delivery, immunotherapy support, and combined diagnostic-therapeutic applications. Surface engineering with polymers, peptides, antibodies, and ligands further improves circulation time, biocompatibility, and receptor-specific uptake. Recent developments from 2023 to 2026 indicate increasing translational potential of multifunctional magnetic nanoplatforms for personalized cancer treatment. However, challenges such as toxicity, aggregation, immune recognition, scalable manufacturing, and regulatory approval remain significant barriers. This comprehensive review discusses recent progress in magnetic nanoparticles for targeted cancer therapy, including classification, synthesis methods, targeting mechanisms, therapeutic applications, safety concerns, and future perspectives.</span></p>